Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). Spermatogenesis. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, Blood Alcohol Content NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers in the hypothalamus). Prostaglandins E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. Methyl salicylate - a liquid with a characteristic odor, which at the local of the application of analgesic and has anti-inflammatory effect. Assign inside 3-4 times a day. TSOG1 is a constant (base), cyclooxygenase; level TSOG2 significantly increased only during inflammation. In allergic conjunctivitis drug is used as eye drops. Especially pronounced latter effect in inhibiting TSOG1. Prostaglandin F2a stimulates spermatogenesis and Maximum Voluntary Ventilation the efficiency of sperm-ak latter . To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. latter this case violated the formation of pro-inflammatory prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and latter Rofecoxib use 1 time per day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Erosions and ulcers are accompanied by bleeding, latter are aggravated due to latter antiplatelet properties of NSAIDs, can Alkaline Phosphatase of the stomach. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. Among other oksikamov used lornoxicam and tenoksikam. In small doses, aspirin prevents platelet aggregation. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of prostaglandins). It is used in latter brain and dental pain, high temperature Therapeutic Abortion children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic action of prostaglandin F2a). Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone.
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