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In this connection, is becoming more widely used, both independently and in combination with other drugs - Amidopyrine, caffeine and so on. Analgin - has a very pronounced analgesic, anti-inflammatory and antipyretic properties. Used for the treatment of rheumatism in the acute form, polyarthritis, gout, erythema impressed and so on. Subcutaneous injections are painful, you may experience irritation of the tissues. Soluble drug, it is convenient for use in cases where the need to quickly establish in the blood high concentration of the drug. Analgesics this group with the therapeutic point of view of interest antifibrin entered into practice in 1886 and received shortly after phenacetin. Higher doses of palladium adults inside - 1 g (single), 3 g (daily). Phenacetin - used in neuralgic pains, especially the head, inflammatory diseases. When the local application also provides a hemostatic action: 1020% solution for wetting tampons for bleeding from the nose. Antipyrine - of pyrazolone derivatives, first introduced in therapy (1884 city, Amidopyrine synthesized three years later). The drug is rapidly absorbed and relatively long in the blood. Phenylbutazone contraindicated in peptic ulcer disease (gastric bleeding may be) disease of blood-forming organs, leukopenia, and abnormal liver function and kidney failure, heart rhythm abnormalities. Amidopyrine excreted in the urine can give it a dark yellow or red. Paracetamol - chemically similar to phenacetin on analgesic activity is not significantly different from him, yet not so toxic and in Zidovudine application is less likely possibility of the formation of methemoglobin.